Sharing, curation, and use of data for a continuously learning health system hold great potential in wide and far reaching areas such as clinical care, patient engagement, informed clinical choice, quality improvement, drug and device safety, effectiveness assessments, and scientific discovery. But to achieve this, an unprecedented level of collaboration among and communication between all stakeholders in the health system is required. This paper calls for three key considerations: (1) Foster a culture of data sharing, (2) Create the operational functionality for data sharing, and (3) Build the continuous data-sharing improvement capacity.